A couple of years ago, me and a friend, blissfully ignorant as we were, rented bikes in Pokhara and cycled to Jomsom -- it's nominally ~160km one way. As it was rain-season, it turned out to be a mad endeavor, and for all the mud very hard at the time (up in 5 days; down in 4). Thankfully, no leeches there.
Of course, now I want to do the full Annapurna circuit on bike, and hopefully see some mountain peaks.
If that kind of thing sounds fun to you, drop a note, let's chat. Thanks.